On the other hand, pistachio and cashew, as you know, demonstrate a great deal of cross-reactivity based on in vitro studies.Ī similar profile is seen when one looks at case reports of patients reacting to mango. Thus, based upon in vitro studies, there has been surprisingly little cross-reactivity demonstrated between mango pulp and pistachio and cashew. However, this cross-reactivity did not extend to mango pulp, although it was present in mango seed (4). However, such cross-reactivity probably occurs less frequently than predicted by the biological taxonomy of these foods (3).Ĭross-reactivity has, as you know, been shown to exist between cashew and pistachio nut. Based upon the biological family containing mango, pistachio and cashew nut, one would expect there to be cross-reactivity between mango and these two nuts. Thus, the allergen profile of mango is complicated, and cross-reactivity spanning many other foods has been shown in vitro. Mango has also demonstrated cross-reactivity to foods in the "latex-fruit cross-reactivity syndrome." A chitinase-like protein cross-reacting with latex has been found in mango as well as avocado, chestnut, banana, kiwi, tomato, passion fruit, and papaya. There is a panallergen found in celery, carrot, apple, peanut, paprika, anise, fennel, coriander, and cumin that demonstrates cross-reactivity with mango. For example, there is a fruit profilin in mango which is also found in pear, peach, and apple. Mango contains a number of different allergens which are found in many other foods besides pistachio and cashew. Thus, although the exact incidence of reactions to mango remains unestablished, it is obvious that compared to other foods, reactions to mango occur less frequently. In another study carried out over nine years, in 580 patients with food allergy, mango was responsible for 6% of the foods to which patients reacted.
MANGO CROSS REACTIVITY SERIES
For example, in a series of 132 children, ages 3 to 19 years, there was one case of mango allergy compared to cow's milk in which there were 11 cases (1). However, there have been series of patients with food allergy where the incidence of reactions to mango has been compared with that to other foods. The exact incidence of mango allergy is unknown.
When a patient has an IgE reaction to mango, what is his risk of cross reactivity with cashew and pistachio, and vice-versa?Īs you know, the evergreen tree family includes mango, pistachio, cashew, and poison ivy. For your convenience, I have copied below our response to a previous very similar inquiry which was posted on May 12. Our Ask the Expert website has recently dealt with the issue of mango cross-reactivity with cashew and pistachio. Should a patient with proven allergy to cashew and pistachio always be told to avoid mango or should a separate evaluation for mango allergy be carried out on a case by case basis? Thank you for your advice and help. Mango cross-reactivity with cashew and pistachio Thank you again for your inquiry and we hope this response is helpful to you. In addition, copied below is an abstract and two website links which should be of help to you in regards to your inquiry. We have discussed this issue on our website previously, and for your convenience, this discussion is copied for you below. There is cross-reactivity between papaya, mango and cashew nuts.
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